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Since the launch of the region’s first Personalised Precision Medicine Programme for Oncology in October 2022, the Department of Health – Abu Dhabi (DoH), together with strategic partners, has offered tailored treatment plans to 256 Emirati cancer patients in Abu Dhabi and personalised prevention plans.
As part of the programme, a select group of cancer patients received personalised treatment and prevention plans from genetic counsellors and specialists to enhance treatment efficiency and recovery. Eligible patients underwent screening for 47 genes to improve their clinical care. To mitigate tumour development risk, the programme tailored preventive plans for 207 family members of patients who tested positive for inherited gene mutations linked to specific cancers. This proactive approach ensures the implementation of effective measures to lower cancer risk in future generations.
As part of the programme, 200 additional patients aged between 25 and 50 years old have been randomly selected from the Emirati Genome Programme (EGP) to test for gene variants that put them at higher risk of developing breast, ovarian, colorectal and lung cancer. Those identified as high-risk received tailored prevention plans. High-risk asymptomatic individuals were also directed to specialised clinics for close monitoring, intervention and lifestyle modifications.
Dr Asma Ibrahim Al Mannaei, the Executive Director of the Research and Innovation Centre at the Department of Health – Abu Dhabi (DoH), said: “In an ever-evolving sector such as healthcare, it is crucial for stakeholders from both public and private sectors to come together to address the most common diseases, improve patient outcomes and enhance therapeutics in line with international standards and best practices. With genomic technologies transforming healthcare, the Department of Health – Abu Dhabi and its partners have an unparalleled ability to make gene discoveries, untangle molecular pathways and find new targets for biomarkers and therapies. Based on this proactive approach, we aim to address the process of diagnostics, drug therapy and prevention, tailoring it to the needs of individuals, further reinforcing the emirate’s position as a prominent destination for life sciences.”
“Our ambitions for the Abu Dhabi Precision Medicine Programme extend beyond oncology – over the next period, we aim to consolidate learnings, unify efforts and address other chronic diseases hindering the health and wellbeing of community members. We’re proud of the programme’s outcomes thus far and remain committed to applying innovation and research to advance precision medicine outcomes, leading the way in defining preventive plans and strategies from Abu Dhabi to the world.”
Dr Stephen Grobmyer, Chair of the Oncology Institute at Cleveland Clinic Abu Dhabi, said: “This groundbreaking initiative has been made possible by the visionary leadership of the UAE, along with the unwavering support of M42 and the Department of Health – Abu Dhabi. Their commitment to advancing healthcare in the country is truly commendable. The programme is a critical step toward implementing effective cancer prevention and treatment schemes on a national level. By leveraging our unique resources and expertise, we aim to deepen our understanding of cancer prevention and treatments across diverse populations, significantly reducing the burden on patients affected by cancer.”
The programme’s impact on the community has been profound, tailoring therapies to individual genetic profiles and identified mutations. It has enhanced treatment efficacy, reduced adverse effects, and provided personalised treatment plans while also mitigating treatment resistance and delivering valuable prognostic insights.
In line with its commitment to advancing oncology care, DoH recently released guidelines for germline testing of breast and ovarian cancer-associated genes to improve diagnosis, treatment, and prevention approaches.
Launched by DoH in collaboration with Cleveland Clinic Abu Dhabi and G42 Healthcare in 2022, the Personalised Precision Medicine Programme for Oncology in the region aims to enhance genomic screening, disease prevention, diagnostic processes, and advanced therapeutic decision-making for breast cancer patients. In addition to reducing the risk or recurrence of the disease, the programme builds on DoH’s mission to drive the future of the healthcare sector with breakthrough technologies and position Abu Dhabi as an innovation hub for life sciences.